Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice.

ABSTRACT: Inhibition of the mTOR (mechanistic target of rapamycin) signaling pathway by the FDA-approved drug rapamycin promotes life span in numerous model organisms and delays age-related disease in mice. However, the utilization of rapamycin as a therapy for age-related diseases will likely prove challenging due to the serious metabolic and immunological side effects of rapamycin in humans. We recently identified an intermittent rapamycin treatment regimen-2mg/kg administered every 5 days-with a reduced impact on glucose homeostasis and the immune system as compared with chronic treatment; however, the ability of this regimen to extend life span has not been determined. Here, we report for the first time that an intermittent rapamycin treatment regimen starting as late as 20 months of age can ext

SUBMITTER: Arriola Apelo SI 

PROVIDER: S-EPMC4906329 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature