Association between clinical antibiotic resistance and susceptibility of Pseudomonas in the cystic fibrosis lung.

ABSTRACT:

Background and objectives

Cystic fibrosis patients suffer from chronic lung infections that require long-term antibiotic therapy. Pseudomonas readily evolve resistance, rendering antibiotics ineffective. In vitro experiments suggest that resistant bacteria may be treated by exploiting their collateral sensitivity to other antibiotics. Here, we investigate correlations of sensitivity and resistance profiles of Pseudomonas aeruginosa that naturally adapted to antibiotics in the cystic fibrosis lung.

Methodology

Resistance profiles for 13 antibiotics were obtained using broth dilution, E-test and VITEK mass spectroscopy. Genetic variants were determined from whole-genome sequences and interrelationships among isolates were analyzed using 13 MLST loci.

Result

Our study fo

SUBMITTER: Jansen G 

PROVIDER: S-EPMC4906436 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature