Thrombocytopenia in Small-for-Gestational-Age Infants.

ABSTRACT:

Background

Thrombocytopenia is common among small-for-gestational-age (SGA) neonates (birth weight <10th percentile reference range), but several aspects of this thrombocytopenia are unclear, including the incidence, typical nadir, duration, association with preeclampsia, mechanism, and risk of death.

Methods

Using 9 years of multihospital records, we studied SGA neonates with ≥2 platelet counts <150,000/μL in their first week.

Results

We found first-week thrombocytopenia in 31% (905 of 2891) of SGA neonates versus 10% of non-SGA matched controls (P < .0001). Of the 905, 102 had a recognized cause of thrombocytopenia (disseminated intravascular coagulation, early-onset sepsis, or extracorporeal membrane oxygenation). This group had a 65% mortality rate. The remaining

SUBMITTER: Christensen RD 

PROVIDER: S-EPMC4906543 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature