Fluorescence imaging to localize head and neck squamous cell carcinoma for enhanced pathological assessment.

ABSTRACT: Accurately identifying close or positive margins in real-time permits re-excision during surgical procedures. Intraoperative assessment of margins via gross examination and frozen section is a widely used tool to assist the surgeon in achieving complete resection. While this methodology permits diagnosis of freshly resected tissue, the process is fraught with misinterpretation and sampling errors. During fluorescence-guided surgery, an exogenous fluorescent agent specific for the target disease is imaged in order to navigate the surgical excision. As this technique quickly advances into the clinic, we hypothesize that the disease-specific fluorescence inherently contained within the resected tissues can be used to guide histopathological assessment. To evaluate the feasibility of fluoresce

SUBMITTER: Warram JM 

PROVIDER: S-EPMC4907060 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature