Identification of key genes associated with cervical cancer by comprehensive analysis of transcriptome microarray and methylation microarray.

ABSTRACT: Cervical cancer is the second most commonly diagnosed type of cancer and the third leading cause of cancer-associated mortality in women. The current study aimed to determine the genes associated with cervical cancer development. Microarray data (GSE55940 and GSE46306) were downloaded from Gene Expression Omnibus. Overlapping genes between the differentially expressed genes (DEGs) in GSE55940 (identified by Limma package) and the differentially methylated genes were screened. Gene Ontology (GO) enrichment analysis was subsequently performed for these genes using the ToppGene database. In GSE55940, 91 downregulated and 151 upregulated DEGs were identified. In GSE46306, 561 overlapping differentially methylated genes were obtained through the differential methylation analysis at the CpG site

SUBMITTER: Liu MY 

PROVIDER: S-EPMC4907103 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature