Analysis of age-dependent trends in Ov16 IgG4 seroprevalence to onchocerciasis.

ABSTRACT:

Background

Diagnostics provide a means to measure progress toward disease elimination. Many countries in Africa are approaching elimination of onchocerciasis after successful implementation of mass drug administration programs as well as vector control. An understanding of how markers for infection such as skin snip microfilaria and Onchocerca volvulus-specific seroconversion perform in near-elimination settings informs how to best use these markers.

Methods

All-age participants from 35 villages in Togo were surveyed in 2013 and 2014 for skin snip Onchocerca volvulus microfilaria and IgG4 antibody response by enzyme-linked immunosorbent assay (ELISA) to the Onchocerca volvulus-specific antigen Ov16. A Gaussian mixture model applying the expectation-maximization (EM) algorith

SUBMITTER: Golden A 

PROVIDER: S-EPMC4907250 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature