Antiepileptic ceramides from the Red Sea sponge Negombata corticata.

ABSTRACT: A new antiepileptic ceramide mixture 1 was isolated from the Red Sea sponge Negombata corticata. The structures of the metabolites were determined by extensive spectroscopic analysis. The anticonvulsant activity of 1 was measured in vivo using the pentylenetetrazole-induced seizure model. This finding has important implications for biological studies with this class of compounds.

SUBMITTER: Ahmed SA 

PROVIDER: S-EPMC4907267 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature