Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma.

ABSTRACT:

Background

Prenatal and infant acetaminophen exposure has been associated with an increased risk of childhood asthma phenotypes. Demonstration of biologically plausible interactions between these exposures and maternal and child antioxidant gene polymorphisms would strengthen causal inference.

Objective

To explore potential interactions between prenatal and infant acetaminophen exposure and antioxidant genotypes on childhood asthma.

Methods

In the Avon Longitudinal Study of Parents and Children, we typed a functional nuclear erythroid 2 p45-related factor 2 (Nrf2) polymorphism and glutathione S-transferase (GST) M1, T1, and P1 polymorphisms. Effects of prenatal and infant acetaminophen exposure on asthma phenotypes at 7 years were stratified by genotype in >4000 mothe

SUBMITTER: Shaheen SO 

PROVIDER: S-EPMC4907348 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature