Representation and inference of cellular architecture for metabolic reconstruction and modeling.

ABSTRACT:

Motivation

Metabolic modeling depends on accurately representing the cellular locations of enzyme-catalyzed and transport reactions. We sought to develop a representation of cellular compartmentation that would accurately capture cellular location information. We further sought a representation that would support automated inference of the cellular compartments present in newly sequenced organisms to speed model development, and that would enable representing the cellular compartments present in multiple cell types within a multicellular organism.

Results

We define the cellular architecture of a unicellular organism, or of a cell type from a multicellular organism, as the collection of cellular components it contains plus the topological relationships among those components.

SUBMITTER: Paley S 

PROVIDER: S-EPMC4907387 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature