Identifying Key Drivers of the Impact of an HIV Cure Intervention in Sub-Saharan Africa.

ABSTRACT:

Background

It is unknown what properties would be required to make an intervention in low income countries that can eradicate or control human immunodeficiency virus (HIV) without antiretroviral therapy (ART) cost-effective.

Methods

We used a model of HIV and ART to investigate the effect of introducing an ART-free viral suppression intervention in 2022 using Zimbabwe as an example country. We assumed that the intervention (cost: $500) would be accessible for 90% of the population, be given to those receiving effective ART, have sufficient efficacy to allow ART interruption in 95%, with a rate of viral rebound of 5% per year in the first 3 months, and a 50% decline in rate with each successive year.

Results

An ART-free viral suppression intervention with these propert

SUBMITTER: Phillips AN 

PROVIDER: S-EPMC4907418 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature