Dynamic myosin activation promotes collective morphology and migration by locally balancing oppositional forces from surrounding tissue.

ABSTRACT: Migrating cells need to overcome physical constraints from the local microenvironment to navigate their way through tissues. Cells that move collectively have the additional challenge of negotiating complex environments in vivo while maintaining cohesion of the group as a whole. The mechanisms by which collectives maintain a migratory morphology while resisting physical constraints from the surrounding tissue are poorly understood. Drosophila border cells represent a genetic model of collective migration within a cell-dense tissue. Border cells move as a cohesive group of 6-10 cells, traversing a network of large germ line-derived nurse cells within the ovary. Here we show that the border cell cluster is compact and round throughout their entire migration, a shape that is maintained despit

SUBMITTER: Aranjuez G 

PROVIDER: S-EPMC4907723 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature