Differential Gene Expression in Coiled versus Flow-Diverter-Treated Aneurysms: RNA Sequencing Analysis in a Rabbit Aneurysm Model.

ABSTRACT:

Background and purpose

The biologic mechanisms leading to aneurysm healing or rare complications such as delayed aneurysm ruptures after flow-diverter placement remain poorly understood. We used RNA sequencing following implantation of coils or flow diverters in elastase aneurysms in rabbits to identify genes and pathways of potential interest.

Materials and methods

Aneurysms were treated with coils (n = 5) or flow diverters (n = 4) or were left untreated for controls (n = 6). Messenger RNA was isolated from the aneurysms at 4 weeks following treatment. RNA samples were processed by using RNA-sequencing technology and were analyzed by using the Ingenuity Pathway Analysis tool.

Results

With RNA sequencing for coiled versus untreated aneurysms, 464/9990 genes (4.6%) wer

SUBMITTER: Rouchaud A 

PROVIDER: S-EPMC4907800 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature