Automated Hippocampal Subfield Segmentation at 7T MRI.

ABSTRACT:

Background and purpose

High resolution 7T MRI is increasingly used to investigate hippocampal subfields in vivo, but most studies rely on manual segmentation which is labor intensive. We aimed to evaluate an automated technique to segment hippocampal subfields and the entorhinal cortex at 7T MRI.

Materials and methods

The cornu ammonis (CA)1, CA2, CA3, dentate gyrus, subiculum, and entorhinal cortex were manually segmented, covering most of the long axis of the hippocampus on 0.70-mm(3) T2-weighted 7T images of 26 participants (59 ± 9 years, 46% men). The automated segmentation of hippocampal subfields approach was applied and evaluated by using leave-one-out cross-validation.

Results

Comparison of automated segmentations with corresponding manual segmentations yielde

SUBMITTER: Wisse LE 

PROVIDER: S-EPMC4907820 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature