Identification of STOML2 as a putative novel asthma risk gene associated with IL6R.

ABSTRACT:

Background

Functional variants in the interleukin-6 receptor gene (IL6R) are associated with asthma risk. We hypothesized that genes co-expressed with IL6R might also be regulated by genetic polymorphisms that are associated with asthma risk. The aim of this study was to identify such genes.

Methods

To identify genes whose expression was correlated with that of IL6R, we analyzed gene expression levels generated for 373 human lymphoblastoid cell lines by the Geuvadis consortium and for 38 hematopoietic cell types by the Differentiation Map Portal (DMAP) project. Genes correlated with IL6R were then screened for nearby single nucleotide polymorphisms (SNPs) that were significantly associated with both variation in gene expression levels (eSNPs) and asthma risk.

Results

SUBMITTER: Revez JA 

PROVIDER: S-EPMC4907821 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature