Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Right ventricular (RV) functional reserve affects functional capacity and prognosis in patients with pulmonary arterial hypertension (PAH). PAH associated with systemic sclerosis (SSc-PAH) has a substantially worse prognosis than idiopathic PAH (IPAH), even though many measures of resting RV function and pulmonary vascular load are similar. We therefore tested the hypothesis that RV functional reserve is depressed in SSc-PAH patients.

Methods and results

RV pressure-volume relations were prospectively measured in IPAH (n=9) and SSc-PAH (n=15) patients at rest and during incremental atrial pacing or supine bicycle ergometry. Systolic and lusitropic function increased at faster heart rates in IPAH patients, but were markedly blunted in SSc-PAH. The recirculation fra

SUBMITTER: Hsu S 

PROVIDER: S-EPMC4907868 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature