The transcription factor p8 regulates autophagy during diapause embryo formation in Artemia parthenogenetica.

ABSTRACT: Autophagy is an essential homeostatic process by which cytoplasmic components, including macromolecules and organelles, are degraded by lysosome. Increasing evidence suggests that phosphorylated AMP-activated protein kinase (p-AMPK) and target of rapamycin (TOR) play key roles in the regulation of autophagy. However, the regulation of autophagy in quiescent cells remains unclear, despite the fact that autophagy is known to be critical for normal development, regeneration, and degenerative diseases. Here, crustacean Artemia parthenogenetica was used as a model system because they produced and released encysted embryos that enter a state of obligate dormancy in cell quiescence to withstand various environmental threats. We observed that autophagy was increased before diapause stage but dropp

SUBMITTER: Lin C 

PROVIDER: S-EPMC4907998 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature