A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives.

ABSTRACT: In the modern world, a number of therapeutic proteins such as vaccines, antigens, and hormones are being developed utilizing different sophisticated biotechnological techniques like recombinant DNA technology and protein purification. However, the major glitches in the optimal utilization of therapeutic proteins and peptides by the oral route are their extensive hepatic first-pass metabolism, degradation in the gastrointestinal tract (presence of enzymes and pH-dependent factors), large molecular size and poor permeation. These problems can be overcome by adopting techniques such as chemical transformation of protein structures, enzyme inhibitors, mucoadhesive polymers and permeation enhancers. Being invasive, parenteral route is inconvenient for the administration of protein and peptides,

SUBMITTER: Muheem A 

PROVIDER: S-EPMC4908063 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature