High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice.

ABSTRACT:

Background and purpose

The link between type 2 diabetes mellitus (T2DM) and depression is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic-like/depressive-like symptoms or alter the efficacy of antidepressant drugs remains poorly documented. This study explored the influence of T2DM on emotionality and proposed a therapeutic strategy that might be used in depressed diabetic patients.

Experimental approach

Mice were fed a high-fat diet (HFD) and subjected to a full comprehensive metabolic and behavioural analysis to establish correlations between metabolic and psychiatric disorders. In vivo intra-hippocampal microdialysis was also applied to propose a mechanism underpinning the phenotype of mice fed the HFD. Finally, we tested whether chr

SUBMITTER: Zemdegs J 

PROVIDER: S-EPMC4908198 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature