Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies.

ABSTRACT:

Objective

 To quantify the dose-response relation between consumption of whole grain and specific types of grains and the risk of cardiovascular disease, total cancer, and all cause and cause specific mortality.

Data sources

 PubMed and Embase searched up to 3 April 2016.

Study selection

 Prospective studies reporting adjusted relative risk estimates for the association between intake of whole grains or specific types of grains and cardiovascular disease, total cancer, all cause or cause specific mortality.

Data synthesis

 Summary relative risks and 95% confidence intervals calculated with a random effects model.

Results

 45 studies (64 publications) were included. The summary relative risks per 90 g/day increase in whole grain intake (90 g is equivalent

SUBMITTER: Aune D 

PROVIDER: S-EPMC4908315 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature