Influence maximization in time bounded network identifies transcription factors regulating perturbed pathways.

ABSTRACT:

Motivation

To understand the dynamic nature of the biological process, it is crucial to identify perturbed pathways in an altered environment and also to infer regulators that trigger the response. Current time-series analysis methods, however, are not powerful enough to identify perturbed pathways and regulators simultaneously. Widely used methods include methods to determine gene sets such as differentially expressed genes or gene clusters and these genes sets need to be further interpreted in terms of biological pathways using other tools. Most pathway analysis methods are not designed for time series data and they do not consider gene-gene influence on the time dimension.

Results

In this article, we propose a novel time-series analysis method TimeTP for determining trans

SUBMITTER: Jo K 

PROVIDER: S-EPMC4908359 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature