A cross-species bi-clustering approach to identifying conserved co-regulated genes.

ABSTRACT:

Motivation

A growing number of studies have explored the process of pre-implantation embryonic development of multiple mammalian species. However, the conservation and variation among different species in their developmental programming are poorly defined due to the lack of effective computational methods for detecting co-regularized genes that are conserved across species. The most sophisticated method to date for identifying conserved co-regulated genes is a two-step approach. This approach first identifies gene clusters for each species by a cluster analysis of gene expression data, and subsequently computes the overlaps of clusters identified from different species to reveal common subgroups. This approach is ineffective to deal with the noise in the expression data introduced

SUBMITTER: Sun J 

PROVIDER: S-EPMC4908362 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature