DFLpred: High-throughput prediction of disordered flexible linker regions in protein sequences.

ABSTRACT:

Motivation

Disordered flexible linkers (DFLs) are disordered regions that serve as flexible linkers/spacers in multi-domain proteins or between structured constituents in domains. They are different from flexible linkers/residues because they are disordered and longer. Availability of experimentally annotated DFLs provides an opportunity to build high-throughput computational predictors of these regions from protein sequences. To date, there are no computational methods that directly predict DFLs and they can be found only indirectly by filtering predicted flexible residues with predictions of disorder.

Results

We conceptualized, developed and empirically assessed a first-of-its-kind sequence-based predictor of DFLs, DFLpred. This method outputs propensity to form DFLs for e

SUBMITTER: Meng F 

PROVIDER: S-EPMC4908364 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature