Ontology highlight
ABSTRACT:
SUBMITTER: Park JG
PROVIDER: S-EPMC4908383 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20160615
Adipose tissue lipolysis produces glycerol and nonesterified fatty acids (NEFA) that serve as energy sources during nutrient scarcity. Adipose tissue lipolysis is tightly regulated and excessive lipolysis causes hepatic steatosis, as NEFA released from adipose tissue constitutes a major source of TG in the liver of patients with nonalcoholic fatty liver diseases. Here we show that the liver-enriched transcription factor CREBH is activated by TG accumulation and induces FGF21, which suppresses ad ...[more]