Eco-friendly synthesis, physicochemical studies, biological assay and molecular docking of steroidal oxime-ethers.

ABSTRACT: The aim of this study was to report the synthesis of biologically active compounds; 7-(2'-aminoethoxyimino)-cholest-5-ene (4), a steroidal oxime-ether and its derivatives (5, 6) via a facile microwave assisted solvent free reaction methodology. This new synthetic, eco-friendly, sustainable protocol resulted in a remarkable improvement in the synthetic efficiency (85-93 % yield) and high purity using basic alumina. The synthesized compounds were screened for their antibacterial against six bacterial strains by disc diffusion method and antioxidant potential by DPPH assay. The binding capabilities of a compound 6 exhibiting good antibacterial potential were assessed on the basis of molecular docking studies and four types of three-dimensional molecular field descriptors. Moreover the structu

SUBMITTER: Alam M 

PROVIDER: S-EPMC4908662 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature