Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes.

ABSTRACT:

Background

Specific language impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10 % of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. Replications of these findings are particularly challenging because the availability of parental DNA is required.

Methods

We used two independent family-based cohorts characterised with reading- and language-related traits: a longitudinal cohort (n = 106 informative families) including ch

SUBMITTER: Pettigrew KA 

PROVIDER: S-EPMC4908686 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature