Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study).

ABSTRACT:

Background

The epidemiology of atrial fibrillation (AF) without comorbidities, known as 'lone AF', is uncertain. Although it has been considered a benign condition, we hypothesized that it confers a worse prognosis compared with a matched sample without AF.

Methods

We described the proportion of AF without comorbidities (clinical, subclinical cardiovascular disease and triggers) among the entire AF sample in Framingham Heart Study (FHS). We compared AF without comorbidities with typical AF, and age-, sex- and cohort-matched individuals without AF, using Cox proportional hazards analysis in relation to combined cardiovascular events (stroke, heart failure, myocardial infarction), and mortality.

Results

Of 10,311 FHS participants, 1,961 were diagnosed with incident AF,

SUBMITTER: Kim EJ 

PROVIDER: S-EPMC4908973 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature