Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation.

ABSTRACT: Gradient-directed cell migration (chemotaxis) and growth (chemotropism) are processes that are essential to the development and life cycles of all species. Cells use surface receptors to sense the shallow chemical gradients that elicit chemotaxis and chemotropism. Slight asymmetries in receptor activation are amplified by downstream signaling systems, which ultimately induce dynamic reorganization of the cytoskeleton. During the mating response of budding yeast, a model chemotropic system, the pheromone receptors on the plasma membrane polarize to the side of the cell closest to the stimulus. Although receptor polarization occurs before and independently of actin cable-dependent delivery of vesicles to the plasma membrane (directed secretion), it requires receptor internalization. Phosphor

SUBMITTER: Ismael A 

PROVIDER: S-EPMC4908976 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature