SHV-129: A Gateway to Global Suppressors in the SHV β-Lactamase Family?

ABSTRACT: Enzymes are continually evolving in response to environmental pressures. In order to increase enzyme fitness, amino acid substitutions can occur leading to a changing function or an increased stability. These evolutionary drivers determine the activity of an enzyme and its success in future generations in response to changing conditions such as environmental stressors or to improve physiological function allowing continual persistence of the enzyme. With recent warning reports on antibiotic resistance and multidrug resistant bacterial infections, understanding the evolution of β-lactamase enzymes, which are a large contributor to antibiotic resistance, is increasingly important. Here, we investigated a variant of the SHV β-lactamase identified from a clinical isolate of Escherichia coli in

SUBMITTER: Winkler ML 

PROVIDER: S-EPMC4909130 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature