Differential and cross-transcriptional control of duplicated genes encoding alternative sigma factors in Streptomyces ambofaciens.

ABSTRACT: The duplicated hasR and hasL genes of Streptomyces ambofaciens encode alternative sigma factors (named sigma(B(R)) and sigma(B(L))) belonging to the sigma(B) general stress response family in Bacillus subtilis. The duplication appears to be the result of a recent event that occurred specifically in S. ambofaciens. The two genes are 98% identical, and their deduced protein products exhibit 97% identity at the amino acid level. In contrast with the coding sequences, their genetic environments and their transcriptional control are strongly divergent. While hasL is monocistronic, hasR is arranged in a polycistronic unit with two upstream open reading frames, arsR and prsR, that encode putative anti-anti-sigma and anti-sigma factors, respectively. Transcription of each has gene is initiated fro

SUBMITTER: Roth V 

PROVIDER: S-EPMC490935 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature