Integrated analysis of the Plasmodium species transcriptome.

ABSTRACT: The genome sequence available for different Plasmodium species is a valuable resource for understanding malaria parasite biology. However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. Here, we developed a comprehensive approach to measure transcriptional changes of the evolutionary conserved syntenic orthologs during the intraerythrocytic developmental cycle across six Plasmodium species. We show significant transcriptional constraint at the mid-developmental stage of Plasmodium species while the earliest stages of parasite development display the greatest transcriptional variation associated with c

SUBMITTER: Hoo R 

PROVIDER: S-EPMC4909483 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature