Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

ABSTRACT:

Background & aims

Known genetic factors explain only a small fraction of genetic variation in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk loci for CRC.

Methods

This discovery stage included 8027 cases and 22,577 controls of East-Asian ancestry. Promising variants were evaluated in studies including as many as 11,044 cases and 12,047 controls. Tumor-adjacent normal tissues from 188 patients were analyzed to evaluate correlations of risk variants with expression levels of nearby genes. Potential functionality of risk variants were evaluated using public genomic and epigenomic databases.

Results

We identified 4 loci associated with CRC risk; P values for the most significant variant in each locus ranged from 3.92 × 10(-8) to 1.2

SUBMITTER: Zeng C 

PROVIDER: S-EPMC4909543 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature