Spatiotemporal Fractionation Schemes for Irradiating Large Cerebral Arteriovenous Malformations.

ABSTRACT:

Purpose

To optimally exploit fractionation effects in the context of radiosurgery treatments of large cerebral arteriovenous malformations (AVMs). In current practice, fractionated treatments divide the dose evenly into several fractions, which generally leads to low obliteration rates. In this work, we investigate the potential benefit of delivering distinct dose distributions in different fractions.

Methods and materials

Five patients with large cerebral AVMs were reviewed and replanned for intensity modulated arc therapy delivered with conventional photon beams. Treatment plans allowing for different dose distributions in all fractions were obtained by performing treatment plan optimization based on the cumulative biologically effective dose delivered at the end of treatm

SUBMITTER: Unkelbach J 

PROVIDER: S-EPMC4909567 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature