Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer.

ABSTRACT:

Background

In the Prostate Cancer Prevention Trial, finasteride selectively suppressed low-grade prostate cancer and significantly reduced the incidence of prostate cancer in men treated with finasteride compared with placebo. However, an apparent increase in high-grade disease was also observed among men randomized to finasteride. We aimed to determine why and hypothesized that there is a grade-dependent response to finasteride.

Methods

From 2007 to 2012, we randomized dynamically by intranet-accessible software 183 men with localized prostate cancer to receive 5mg finasteride or placebo daily in a double-blind study during the 4-6weeks preceding prostatectomy. As the primary end point, the expression of a predefined molecular signature (ERβ, UBE2C, SRD5A2, and VEGF) differ

SUBMITTER: Kim J 

PROVIDER: S-EPMC4909608 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature