Breast-feeding, aeroallergen sensitization, and environmental exposures during infancy are determinants of childhood allergic rhinitis.

ABSTRACT:

Background

Infant predictors of early childhood allergic rhinitis (AR) are poorly understood.

Objective

We sought to identify environmental exposures and host factors during infancy that predict AR at age 3 years.

Methods

High-risk children from greater Cincinnati were followed annually from ages 1 to 3 years. AR was defined as sneezing, runny, or blocked nose in the prior 12 months and a positive skin prick test (SPT) response to 1 or more aeroallergens. Environmental and standardized medical questionnaires determined exposures and clinical outcomes. Primary activity area dust samples were analyzed for house dust endotoxin (HDE) and (1-3)-beta-D-glucan. Fine particulate matter sampled at 27 monitoring stations was used to estimate personal elemental carbon attributab

SUBMITTER: Codispoti CD 

PROVIDER: S-EPMC4910509 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature