Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest.

ABSTRACT:

Background/aims

The increased occurrence of type 2 diabetes and its clinical correlates is a global public health issue, and there are continued efforts to find its genetic determinant across ethnically diverse populations. The aims of this study were to determine the heritability of diabetes and metabolic syndrome phenotypes in the Arizona Insulin Resistance (AIR) registry and to perform an association analysis of common single nucleotide polymorphisms (SNPs) identified by GWAS with these traits. All study participants were Mexican Americans from the AIR registry.

Methods

Metabolic, anthropometric, demographic and medical history information was obtained on the 667 individuals enrolled in the registry.

Results

The heritability estimates were moderate to high in magni

SUBMITTER: DeMenna J 

PROVIDER: S-EPMC4910511 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature