Parental epigenetic asymmetry of PRC2-mediated histone modifications in the Arabidopsis endosperm.

ABSTRACT: Parental genomes in the endosperm are marked by differential DNA methylation and are therefore epigenetically distinct. This epigenetic asymmetry is established in the gametes and maintained after fertilization by unknown mechanisms. In this manuscript, we have addressed the key question whether parentally inherited differential DNA methylation affects de novo targeting of chromatin modifiers in the early endosperm. Our data reveal that polycomb-mediated H3 lysine 27 trimethylation (H3K27me3) is preferentially localized to regions that are targeted by the DNA glycosylase DEMETER (DME), mechanistically linking DNA hypomethylation to imprinted gene expression. Our data furthermore suggest an absence of de novo DNA methylation in the early endosperm, providing an explanation how DME-mediated

SUBMITTER: Moreno-Romero J 

PROVIDER: S-EPMC4910532 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature