Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway.

ABSTRACT:

Background

AMPactivated protein kinase α (AMPKα) is closely involved in the process of cardiac hypertrophy. Asiatic acid (AA), a pentacyclic triterpene, was found to activate AMPKα in our preliminary experiment. However, its effects on the development of cardiac hypertrophy remain unclear. The present study was to determine whether AA could protect against cardiac hypertrophy.

Methods

Mice subjected to aortic banding were orally given AA (10 or 30mg/kg) for 7 weeks. In the inhibitory experiment, Compound C was intraperitoneally injected for 3 weeks after surgery.

Results

Our results showed that AA markedly inhibited hypertrophic responses induced by pressure overload or angiotensin II. AA also suppressed cardiac fibrosis in vivo and accumulation of collagen in vitro.

SUBMITTER: Ma ZG 

PROVIDER: S-EPMC4910604 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature