Ontology highlight
ABSTRACT:
SUBMITTER: Cottone L
PROVIDER: S-EPMC4910728 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Oncoimmunology 20160108 5
The factors that determine whether disseminated transformed cells in vivo yield neoplastic lesions have only been partially identified. We established an ad hoc model of peritoneal carcinomatosis by injecting colon carcinoma cells in mice. Tumor cells recruit inflammatory leukocytes, mostly macrophages, and generate neoplastic peritoneal lesions. Phagocyte depletion via clodronate treatment reduces neoplastic growth. Colon carcinoma cells release a prototypic damage-associated molecular pattern ...[more]