From genetics to treatment of eosinophilic esophagitis.

ABSTRACT:

Purpose of review

Eosinophilic Esophagitis (EoE) is an emerging chronic atopic disease. Recent advances in understanding its genetic and molecular biology pathogenesis may lead to a better management of the disease

Recent findings

EoE is an atopic disease. Most of the patients affected by EoE have other atopic diseases such as allergic rhinitis, asthma, IgE-mediated food allergies and/or atopic dermatitis. The local inflammation is a T helper type 2 (Th2) flogosis, which most likely is driven by a mixed IgE and n-IgE-mediated reaction to food and/or environmental allergens. Epidemiological studies show that EoE is an atopic disease with a strong genetic component. Genetic studies have shown that EoE is associated with single nucleotide polymorphism on genes, which are releas

SUBMITTER: Cianferoni A 

PROVIDER: S-EPMC4910818 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature