Decreased MicroRNA-26a expression causes cisplatin resistance in human non-small cell lung cancer.

ABSTRACT: BACKGROUND:Lung cancer is the most common cancer that is caused by perturbation of regulatory pathways rather than dysfunction of a single gene. Cisplatin (CDDP; cis-diamminedichloroplatinum II) is the first member of a class of platinum-containing anti-cancer medication, which binds to DNA and triggers apoptosis. CDDP-based chemotherapy is used to treat various types of cancers. However, the efficacy of CDDP in the treatment of non-small-cell lung cancer (NSCLC) is limited by acquired drug resistance. MicroRNAs have recently emerged as key regulators of cancers, and miR-26a is one of down-regulated miRNAs in A549/CDDPres cell line. This study aimed to investigate the role of miR-26a in CDDP resistance in NSCLC as well as the underlying mechanisms. METHODS:In this study, we analyzed expres

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4910912 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature