Association of Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer in a Saudi Arabian Population.

ABSTRACT:

Background

Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). VDR is a transcription factor modulating the expression of several genes in different pathways. Genetic variants in the VDR gene have been associated with several cancers in different population including colorectal cancer.

Objective

To assess the association of VDR gene polymorphisms in relation with colorectal cancer (CRC) in a Saudi population.

Methods

The polymorphisms of VDR gene (BsmI, FokI, ApaI and TaqI) were analyzed by the polymerase chain reaction amplification of segments of interest followed by Sanger sequencing. One hundred diagnosed CRC patients and 100 healthy control subjects that were age and gender ma

SUBMITTER: Alkhayal KA 

PROVIDER: S-EPMC4911096 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature