The Application of Digital Pathology to Improve Accuracy in Glomerular Enumeration in Renal Biopsies.

ABSTRACT:

Background

In renal biopsy reporting, quantitative measurements, such as glomerular number and percentage of globally sclerotic glomeruli, is central to diagnostic accuracy and prognosis. The aim of this study is to determine the number of glomeruli and percent globally sclerotic in renal biopsies by means of registration of serial tissue sections and manual enumeration, compared to the numbers in pathology reports from routine light microscopic assessment.

Design

We reviewed 277 biopsies from the Nephrotic Syndrome Study Network (NEPTUNE) digital pathology repository, enumerating 9,379 glomeruli by means of whole slide imaging. Glomerular number and the percentage of globally sclerotic glomeruli are values routinely recorded in the official renal biopsy pathology report fro

SUBMITTER: Rosenberg AZ 

PROVIDER: S-EPMC4911144 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature