Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.

ABSTRACT: The goal of brain tumor surgery is to maximize tumor removal without injuring critical brain structures. Achieving this goal is challenging as it can be difficult to distinguish tumor from nontumor tissue. While standard histopathology provides information that could assist tumor delineation, it cannot be performed iteratively during surgery as freezing, sectioning, and staining of the tissue require too much time. Stimulated Raman scattering (SRS) microscopy is a powerful label-free chemical imaging technology that enables rapid mapping of lipids and proteins within a fresh specimen. This information can be rendered into pathology-like images. Although this approach has been used to assess the density of glioma cells in murine orthotopic xenografts models and human brain tumors, tissue he

SUBMITTER: Lu FK 

PROVIDER: S-EPMC4911248 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature