Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease.

ABSTRACT:

Background

Studies suggested that variants in the ABCB1 gene encoding P-glycoprotein, a xenobiotic transporter, may increase susceptibility to pesticide exposures linked to Parkinson's Disease (PD) risk.

Objectives

To investigate the joint impact of two ABCB1 polymorphisms and pesticide exposures on PD risk.

Methods

In a population-based case control study, we genotyped ABCB1 gene variants at rs1045642 (c.3435C/T) and rs2032582 (c.2677G/T/A) and assessed occupational exposures to organochlorine (OC) and organophosphorus (OP) pesticides based on self-reported occupational use and record-based ambient workplace exposures for 282 PD cases and 514 controls of European ancestry. We identified active ingredients in self-reported occupational use pesticides from a California

SUBMITTER: Narayan S 

PROVIDER: S-EPMC4911423 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature