Organic bioelectronics probing conformational changes in surface confined proteins.

ABSTRACT: The study of proteins confined on a surface has attracted a great deal of attention due to its relevance in the development of bio-systems for laboratory and clinical settings. In this respect, organic bio-electronic platforms can be used as tools to achieve a deeper understanding of the processes involving protein interfaces. In this work, biotin-binding proteins have been integrated in two different organic thin-film transistor (TFT) configurations to separately address the changes occurring in the protein-ligand complex morphology and dipole moment. This has been achieved by decoupling the output current change upon binding, taken as the transducing signal, into its component figures of merit. In particular, the threshold voltage is related to the protein dipole moment, while the field-

SUBMITTER: Macchia E 

PROVIDER: S-EPMC4911579 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature