Individualized Map of White Matter Pathways: Connectivity-Based Paradigm for Neurosurgical Planning.

ABSTRACT:

Background

Advances in white matter tractography enhance neurosurgical planning and glioma resection, but white matter tractography is limited by biological variables such as edema, mass effect, and tract infiltration or selection biases related to regions of interest or fractional anisotropy values.

Objective

To provide an automated tract identification paradigm that corrects for artifacts created by tumor edema and infiltration and provides a consistent, accurate method of fiber bundle identification.

Methods

An automated tract identification paradigm was developed and evaluated for glioma surgery. A fiber bundle atlas was generated from 6 healthy participants. Fibers of a test set (including 3 healthy participants and 10 patients with brain tumors) were clustered a

SUBMITTER: Tunc B 

PROVIDER: S-EPMC4911597 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature