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Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro.

ABSTRACT: A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(-) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.

SUBMITTER: Share AI 

PROVIDER: S-EPMC4911636 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro.

Share Andrew I AI   Patel Khushali K   Nativi Cristina C   Cho Eun J EJ   Francesconi Oscar O   Busschaert Nathalie N   Gale Philip A PA   Roelens Stefano S   Sessler Jonathan L JL  

Chemical communications (Cambridge, England) 20160525 48

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(-) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro. ...[more]

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