The Prognostic Value of Circulating Cell-Free DNA in Colorectal Cancer: A Meta-Analysis.

ABSTRACT:

Background

Circulating cell-free DNA (cfDNA) is a promising candidate biomarker for detection, monitoring and survival prediction of colorectal cancer (CRC). However, its prognostic significance for patients with CRC remains controversial. To derive a precise estimation of the prognostic significance of cfDNA, a meta-analysis was performed.

Methods

We made a systematic search in data base of the Science Citation Index Embase and Pubmed for studies reporting prognostic data of cfDNA in CRC patients. The data of cfDNA on recurrences-free survival (RFS) and overall survival (OS) were extracted and measured in hazard rates (HRs) and 95% confident intervals (CIs). Subgroup analyses were carried out as well. Finally, the meta-analysis is accompanied with nine studies including 19

SUBMITTER: Basnet S 

PROVIDER: S-EPMC4911878 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature