Templated Oligosaccharide Synthesis: The Linker Effect on the Stereoselectivity of Glycosylation.

ABSTRACT: A new method for intramolecular oligosaccharide synthesis that is conceptually related to the general molecular clamp approach is introduced. Exceptional α-selectivity has been achieved in a majority of applications. Unlike other related concepts, this approach is based on the bisphenol A template, which allows one to connect multiple building blocks to perform templated oligosaccharide synthesis with complete stereoselectivity. This principle was demonstrated by the synthesis of an α,α-linked trisaccharide.

SUBMITTER: Pornsuriyasak P 

PROVIDER: S-EPMC4912053 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature