Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal.

ABSTRACT: Regeneration of vertebrate skeletal muscles requires satellite cells, a population of stem cells that are quiescent in normal conditions and divide, differentiate, and self-renew upon activation triggered by exercise, injury, and degenerative diseases. Satellite cell self-renewal is essential for long-term tissue homeostasis, and previous work has identified a number of external cues that control this process. However, little is known of the possible intrinsic control mechanisms of satellite cell self-renewal. Here, we show that quiescent satellite cells harbor a primary cilium, which is rapidly disassembled upon entry into the cell cycle. Contrasting with a commonly accepted belief, cilia reassembly does not occur uniformly in cells exiting the cell cycle. We found that primary cilia reas

SUBMITTER: Jaafar Marican NH 

PROVIDER: S-EPMC4912054 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature